The Future Foundation is in shambles after the Final Killing Game and the revelation of the true culprit. As a desperate plot arises from one of the survivors to rid the world of despair once and for all, the remaining Future Foundation members must band together to stop it. Fortunately, they find themselves with help from a group of unlikely allies as they race against the clock to stop their world from being changed.

As a direct continuation of Mirai-hen, Kibou-hen serves as the finale to the Hope's Peak storyline of the Danganronpa series.